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NPS-2143 (SB262470) ,284035-33-2,绲�(ji茅)妲�(g貌u)寮�

NPS-2143 (SB262470)

CasNo:284035-33-2 MDL: 鍒嗗瓙寮�:C24H25ClN2O2 鍒嗗瓙閲�:408.92

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鎴戣濮旀墭閲囪臣 284035-33-2 鐢�(ch菐n)鍝�

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鍩烘湰淇℃伅鐗╁寲鎬ц唱(zh矛)瀹夊叏鏁�(sh霉)鎿�(j霉)

CAS:284035-33-2
涓枃鍚嶏細NPS-2143 (SB262470)
鑻辨枃鍚嶏細NPS-2143 (SB262470)
涓枃鍒ュ悕锛�

鑻辨枃鍒ュ悕锛�

鎶€琛�(sh霉)鍟忕瓟

鍟�NPS-2143鍖垮悕 2021-04-13 15:23
鎻忚堪锛歂PS-2143鏄粈涔堬紝鏈変粈涔堢敤
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NPS-2143 (SB-262470A)锛屽彛鏈嶆椿鎬ф憾閳ｅ姂锛� 鏄伕鎿囨€х殑閳ｆ晱鎰熷彈楂� (CaSR) 鎷姉鍔戙€侼PS-2143 (SB-262470A) 閫氶亷婵€娲昏〃閬�(d谩)浜� Ca2+ 鍙楅珨鐨� HEK 293 绱�(x矛)鑳炰腑鐨� Ca2+ 鍙楅珨鑰屽紩璧风殑鑳炴伎 Ca2+ 婵冨害澧炲姞 (IC50=43 nM)銆�
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鍟�NPS-2143鏈夊暐鎳�(y墨ng)鐢�鍖垮悕 2021-03-04 12:01
鎻忚堪锛歂PS-2143涓昏鏈夊暐宸ユキ(y猫)鐢ㄩ€旓紵
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NPS-2143鏄竴绋柊鍨嬫湁鏁堢殑锛岄伕鎿囨€х殑Ca(2+)鍙楅珨鎷姉鍔戯紝IC50鐐�43 nM銆傝〃閬�(d谩)浜篊a2+鍙楅珨鐨凥EK 293绱�(x矛)鑳炰腑锛孨PS 2143闃绘柗Ca2+鍙楅珨婵€娲昏獦鐧�(f膩)鐨勭窗(x矛)鑳炶唱(zh矛)Ca2+婵冨害澧炲姞锛孖C50鐐�3 nM銆俒1] NPS 2143鍒烘縺鐗涚敳鐙€鏃佽吅绱�(x矛)鑳炰腑鐢茬媭鏃佽吅绱�(PTH)鍒嗘硨锛孍C50 鐐�41 nM銆傛澶栵紝NPS 214鏈冮樆鏂锋摤閳ｅ姂NPS R-467灏峆TH寰炵墰鐢茬媭鏃佽吅绱�(x矛)鑳炲垎娉岀殑鎶戝埗浣滅敤锛屼篃鏈冮樆鏂风窗(x矛)鑳炲Ca2+灏嶇暟涓欒厧涓婅吅绱犲埡婵€鐨勭挵(hu谩n)AMP褰㈡垚澧炲姞鐨勬姂鍒朵綔鐢ㄣ€俒1]鍦ㄧ煭鏆〃閬�(d谩)hCaSRs鐨凥EK-293绱�(x矛)鑳炰腑锛孨PS 2143閫氶亷鏈夋晥鎶戝埗GSH (鏁�(sh霉)鎿�(j霉)鏈’绀�)鍜屛�-Glu-Val-Gly娲绘€э紝椤憲鎶戝埗鍘氬懗鍛宠銆俒3]涓€闋呰繎鏈熺殑鐮旂┒琛ㄦ槑锛孨PS 2143娌荤檪鎶戝埗azuki姘磋В鐗╄獦灏�(d菐o)鐨凜aSR杞�(zhu菐n)鏌撶殑HEK 293绱�(x矛)鑳炰腑锛岃喗鍥婃敹绺礌(CCK)鍒嗘硨鐨勪綆鍒嗗瓙閲忕櫨鍒嗘瘮銆俒4]
灞曢枊
鍟�NPS-2143鐨勫瑙€鍖垮悕 2021-03-04 10:26
鎻忚堪锛歂PS-2143鏄浐楂旈倓鏄恫楂旓紵
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绮夋湯
灞曢枊

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姝ゅ晢鍝佸凡鎴愬姛娣诲姞鍒拌臣鐗╄粖!
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